MEDICUBE Red Serum Plus

MEDICUBE Red Serum Plus

Calm and refresh oily, acne-prone skin with the MEDICUBE Red Serum Plus, a lightweight multi-extract soothing serum from MEDICUBE's Red Line for blemish-prone skin. This fast-absorbing, non-comedogenic formula is packed with 28 plant extracts alongside Niacinamide, Salicylic Acid (BHA), Zinc PCA, 4-Terpineol + Tea Tree Leaf Oil, Dipotassium Glycyrrhizate (Licorice), Dimethyl Sulfone (MSM), Ceramide NP, Panthenol, Allantoin, Adenosine, Centella Asiatica Leaf Extract, Camellia Sinensis (Green Tea) Leaf Extract, Lactococcus Ferment Lysate, Xylitol, and Trehalose — delivering targeted soothing, sebum control, pore care, and lightweight hydration without a sticky finish.

The formula's color may shift from blue to green over time due to natural interactions between Ovalicin and Colloidal Sulfur — this is a normal, expected behavior of the raw ingredients and does not affect product quality or efficacy. Non-comedogenic — safe for acne-prone skin without risk of clogging pores.

The MEDICUBE Red Serum Plus is a great choice for anyone looking for a K-beauty calming serum, lightweight serum for oily skin, or non-comedogenic soothing serum for acne-prone skin. Dermatologically tested — suitable for oily, combination, and sensitive acne-prone skin types.

Size: 30ml / 1.01 fl. oz

Overview

The MEDICUBE Red Serum Plus is a soothing facial serum from MEDICUBE's Red Line, formulated with over 28 plant extracts plus clinically active ingredients for oily and blemish-prone skin. It targets the full scope of daily acne-prone skin care in one lightweight step: soothing active breakout-prone skin, controlling excess sebum, clearing pore buildup, delivering moisture without heaviness, and supporting the skin barrier — all in a fast-absorbing, non-sticky formula suitable for morning and evening use.

Study results

98% customer satisfaction rate. Dermatologically tested as non-irritating. All products from MEDICUBE are clinically tested. Individual results may vary.

Key benefits

• Helps soothe and comfort blemish-prone skin with 28 plant extracts
• Supports sebum control and pore care with Zinc PCA, Salicylic Acid, and Dimethyl Sulfone
• Lightweight, non-comedogenic hydration — no sticky finish
• Formulated with Tea Tree Oil + 4-Terpineol, Niacinamide, Dipotassium Glycyrrhizate, Ceramide NP, and Centella Asiatica
• Fast-absorbing texture for morning and evening use
• Dermatologically tested as non-irritating — for oily, combination, and sensitive acne-prone skin

How to use

After cleansing (and toner if using), apply an appropriate amount to the face and gently pat until fully absorbed. Use morning and evening as part of your daily skincare routine. Follow with MEDICUBE's Red Foam Cleanser for a complete Red Line routine, or layer with any lightweight moisturizer.

Note: The product may shift from blue to green in color over time due to natural interactions between Ovalicin and Colloidal Sulfur in the formula. This is a natural, expected raw material phenomenon and does not indicate a problem with the product.

Why we love it

The MEDICUBE Red Serum Plus is one of the most comprehensively formulated serums in the MEDICUBE Red Line — not because it relies on one or two hero actives, but because it covers every dimension of acne-prone skin care simultaneously in one serum step. The 4-Terpineol + Tea Tree Oil pairing is more nuanced than simply adding tea tree to a formula: 4-Terpineol is the specific antimicrobial and anti-inflammatory compound responsible for tea tree oil's efficacy, isolated and added at concentrated levels alongside the full oil for amplified targeted action. Zinc PCA regulates sebum production specifically rather than simply drying the skin — a meaningful distinction for oily skin that has often become oilier in response to drying treatments. Dipotassium Glycyrrhizate (licorice root derivative) is one of the most effective and well-tolerated natural anti-inflammatory actives in dermatology, addressing the inflammation that underlies redness and breakout formation rather than just the surface symptoms. Dimethyl Sulfone (MSM, methylsulfonylmethane) provides sulfur-based pore-clarifying support that complements the Salicylic Acid's BHA action without additional acid burden. And the 28-extract botanical complex — from Centella Asiatica and Green Tea to Portulaca, Mugwort, Chamomile, and Asiatic Pennywort — provides layered calming, moisturizing, and skin-supporting benefits that make a blemish serum feel genuinely nourishing rather than clinically harsh. At BestSkincareUSA.com, it's the daily treatment serum we recommend most for acne-prone and oily skin in the MEDICUBE lineup, and one of the most intelligently formulated Korean skincare serums for blemish-prone skin.

Key ingredients deeper dive

• 4-Terpineol and Tea Tree Leaf Oil (Melaleuca Alternifolia) — concentrated antimicrobial and anti-inflammatory pairing for blemish-prone skin — 4-Terpineol is the active monoterpenol compound that gives tea tree oil its clinically documented antimicrobial and anti-inflammatory efficacy. By including both the full Tea Tree Leaf Oil and isolated 4-Terpineol, the MEDICUBE Red Serum Plus provides the whole-plant benefit of tea tree alongside a concentrated dose of its most clinically effective component — targeting the Cutibacterium acnes bacteria that drive breakout formation while simultaneously reducing the inflammation that makes existing blemishes more visible and slower to resolve across all Korean skincare skin types.
• Zinc PCA — sebum regulation without the dryness of conventional oil-control ingredients — Zinc PCA (zinc salt of pyrrolidone carboxylic acid) works by inhibiting the activity of 5-alpha reductase — the enzyme that triggers excess sebum production in oily skin — rather than simply absorbing existing oil. This mechanism reduces sebum output at the source rather than just managing the surface appearance, providing more sustained oil control without the dryness that typical mattifying agents cause. It pairs with the Salicylic Acid's pore-penetrating action in the MEDICUBE Red Serum Plus for both sebum-at-source reduction and pore-lining clearance.
• Dipotassium Glycyrrhizate (Licorice Root) — well-tolerated anti-inflammatory for blemish redness and irritation — Dipotassium Glycyrrhizate is a licorice root derivative and one of the most effective naturally derived anti-inflammatory actives in dermatology. It inhibits inflammatory prostaglandin pathways, reducing the redness, swelling, and irritation around breakouts and blemishes — making it a core ingredient in the calming function of the MEDICUBE Red Serum Plus for skin that is sensitized by existing breakout activity.
• Dimethyl Sulfone (MSM) and Salicylic Acid — pore clarification at the surface and within — Dimethyl Sulfone (methylsulfonylmethane) provides organic sulfur that helps clarify the pore opening and skin surface, complementing the Salicylic Acid's oil-soluble, pore-penetrating BHA action. Salicylic Acid dissolves the sebum and dead skin mixture inside the pore from within; MSM addresses the oxidative and surface-level congestion at the pore opening. Together they provide a complete dual-approach pore-clarification system in the leave-on serum format of the MEDICUBE Red Serum Plus.
• 28 plant extracts — a comprehensive botanical calming and moisture complex for blemish-prone skin — The 28-extract complex in the MEDICUBE Red Serum Plus is one of the most extensive in any K-beauty serum format, covering every dimension of skin support for oily and blemish-prone skin: Centella Asiatica (barrier repair and soothing), Camellia Sinensis/Green Tea (antioxidant calming), Portulaca (moisturizing and calming), Japanese Prickly Ash (protection and defense barrier), Mugwort (skin improvement), Chamomile (soothing), Asiatic Pennywort (moisturize and calm), White Willow Bark (gentle exfoliation), Lavender Water (oil control), Rice Extract (soft and hydrated skin), Coffee Seed Extract (antioxidant), Bergamot Leaf Extract, Aloe Barbadensis (hydration and soothing), Turmeric Root (anti-inflammatory), and 14 more. This botanical breadth makes the MEDICUBE Red Serum Plus feel genuinely nourishing rather than harshly acne-clinical.
• Ceramide NP and Lactococcus Ferment Lysate — barrier support and microbiome care for acne-prone skin — Ceramide NP replenishes the lipid barrier that acne-prone skin often has disrupted — supporting the barrier integrity that prevents moisture loss and helps prevent the inflammation triggers that worsen breakout-prone skin. Lactococcus Ferment Lysate provides probiotic-derived microbiome support, helping maintain the balanced skin microbiome that contributes to barrier resilience and reduced acne-causing bacterial imbalance in the MEDICUBE Red Serum Plus.

Who it's for

The MEDICUBE Red Serum Plus is designed specifically for oily, combination, and acne-prone skin — those dealing with blemishes, excess sebum, enlarged pores, redness, and the dehydrated-yet-oily skin condition that harsher acne treatments often create. The non-comedogenic certification and dermatologically tested non-irritating formula make it accessible for sensitive skin that has experienced breakouts. It's especially effective as a daily treatment serum that sits between the MEDICUBE Red Foam Cleanser and moisturizer for a complete Red Line blemish-care daily routine — the cleanser maintains cleansing and sebum management, and this serum delivers the soothing, active, and moisturizing treatment the skin needs between washes.

Pro tips and pairings

Apply the MEDICUBE Red Serum Plus to slightly damp skin for best absorption — the water content helps the lightweight formula distribute evenly before patting. For concentrated blemish care, press additional serum onto active breakout areas and hold gently for 10–15 seconds after the initial full-face application. Do not rub — pat and press for even distribution without disrupting earlier skincare layers. Pair with the MEDICUBE Red Foam Cleanser as the cleansing step for a complete MEDICUBE Red Line daily routine, and add the MEDICUBE 21% Red Succinic Acid Cleansing Booster Serum 2–3 evenings per week as an intensive pore-clearing treatment before this serum. Explore more from MEDICUBE: Shop MEDICUBE